However, rs6679677 also: (1) has eQTLs with AP4B1-AS1 and immune regulation genes (i.e. FOXP3, CTLA4, IL2RA and SLAMF123–26) in whole blood; (2) has been associated with the development of multiple persistent autoantibodies (including islet autoantibody), but not progression to T1D development in the TEDDY prospective cohort27; (3) has been associated with the development of other autoimmune disorders (i.e. juvenile idiopathic arthritis and rheumatoid arthritis)28,29 and (4) was reported as the top non-HLA SNP associated with T1D from WTCCC studies30. Here, CTLA4 is linked to juvenile idiopathic arthritis.