The major contributor eQTL (rs6679677) downregulated AP4B1-AS1 transcript levels in cis (i.e. rs6679677 and AP4B1-AS1 are <1 Mb apart) in the lungs and conferred a 13.3% contribution to the T1D regularised logistic regression predictor. The gene discussed is AP4B1; the disease is type 1 diabetes mellitus.