We integrated a regularised logistic regression model on European ancestry genotypes of T1D case and control to identify transcriptional changes in the lung involving AP4B1-AS1 and CTLA4 (associated with rs6679677) as the largest individual contributors, through a gene regulatory mechanism, to the conversion of the genetic risk for the development of T1D. This evidence concerns the gene CTLA4 and type 1 diabetes mellitus.