The lung eQTL involving rs3087243 and CTLA4 is also notable as: (1) rs3087243 has been linked with progression from single to multiple autoantibodies in the TrialNet PTP cohort11; (2) CTLA4 encodes an immunoglobulin protein crucial for modulating T cell function and mediating autoimmunity and (3) immune intervention trials targeting CTLA4 have reported significant but short-term positive metabolic outcomes12. The gene discussed is CTLA4; the disease is Autoimmunity.