AKT1 and acute lymphoblastic leukemia: Despite the plethora of genetic alterations featuring both myeloid and lymphoid acute leukemias, it is important to consider that most of them lead to the constitutive activation of critical pathways for cell growth including Janus kinase/Signal transducers and transcription activators (JAK-STAT), Phosphoinositide-3-kinase–protein kinase B (PI3K-AKT), Ras mitogen-activated protein kinase (Ras-MAPK), Glycogen synthase kinase-3β (GSK-3β), Hypoxia-inducible transcription factor 1α (HIF-1α) and Nuclear factor-kappa beta (NF-κB) among others4,7.