GDF15 and obesity due to melanocortin 4 receptor deficiency: Accordingly, GDF-15 correlations with IgA and IgG were significant in heavier children (those with BMI-SDS above the median) and in children with higher accumulation of renal fat (those with renal fat-to-height above the median), which give support to a possible role of GDF-15 in obesity-triggered inflammation.