Because the expression of Ki67, p53, and MMP2 has been confirmed to be related to invasion, prognosis, and lymph node metastasis in laryngeal carcinoma, we also analyzed the expression of these three proteins in laryngeal carcinoma, used statistical methods to analyze the correlation between AKR1B10 and these three proteins, and then analyzed whether AKR1B10 can regulate the expression of these three proteins. This evidence concerns the gene MMP2 and metastatic malignant neoplasm in the lymph nodes.