In the network topology analysis, the active ingredients of ginseng leaves have a greater possibility of acting on the immune regulation of lung cancer through HSP90AA1, JUN, STAT3 EGFR, MYC, VEGFA, CCND1, TNF, MAPK1, AKT1, RELA, CDKN1A, IL1B, IL2 and TP53. This evidence concerns the gene CDKN1A and lung cancer.