By using homologous technologies to measure cortical gene expression, we were able to compare changes in cortical gene expression in the Chrm1−/− mouse and BA 9, 10, and 33 from patients with schizophrenia which showed that 47 genes had altered levels of expression in the Chrm1−/− mouse and in BA 10, but not BA 9 or 33, from patients with schizophrenia. This evidence concerns the gene CHRM1 and schizophrenia.