TP53BP1 and leiomyoma: Non-homologous end joining (NHEJ), quantified as nuclei double-positive for γH2Ax (>10 foci) and 53BP1 (>5 foci), was the major DNA repair mechanism induced by stretching in both myometrium (OR = 1.5) and leiomyoma (OR = 2.0; both P < 0.0001; Fig. 4e and Supplementary Fig. 13) cells.