Serum from only four HC recognized a single autoantigen each (signal recognition particle 54, SRP 54; Smith/ribonuclear protein, Sm/RNP; guanosine nucleotide-binding protein alpha subunit, GNAL, a candidate autoantigen in autoimmune hypophysitis; and Ku 70/80, respectively, Fig. 1, middle panel). This evidence concerns the gene GNAL and primary hypophysitis.