Several striking reactivities were observed in individual COVID-19 patients, including IL-12p70 (Subject UP47); the SARS-CoV-2 receptor angiotensin-converting enzyme-2 (ACE-2, Subject UMR19); granulocyte-macrophage colony-stimulating factor which is the causative autoantibody target in PAP (GM-CSF, Subject UP25); oncostatin-M (OSM, Subject UP40); and soluble receptor activator of nuclear factor kappa B (sRANK-ligand, Subject UP19). The gene discussed is ACE2; the disease is COVID-19.