A subset of autoantibodies (e.g., antibodies that bind the complement inhibitor C1q, thrombosis-associated antibodies that target beta 2 glycoprotein 1 (β2-GP1), and vasculitis-associated antigens such as bactericidal permeability inducing protein (BPI)) that have been implicated in pathogenic inflammation in target organs, were also found in individual patients (Fig. 2c)4–6,14–16. The gene discussed is BPI; the disease is vasculitis.