Rare antigens are seen in patients with autoimmune myositis (MDA5, Mi-2, and tRNA synthetases such as PL-7 and Jo-1), and candidate autoantigens in autoimmune myocarditis (troponin and MYH6, Fig. 2a), were observed in individual patients, as were rare SSc autoantigens (Th/To (RPP25), fibrillarin, and the U11/U12 snRNP, Fig. 2b). Here, MYH6 is linked to systemic sclerosis.