For example, the established myeloma cell dependencies and PC lineage-defining TF IRF4, XBP1 and PRDM1, are also predicted to be connected to a higher number of other TF in HD, MMSET and CCND1 subgroups than in ND PC, while TF of the MEF family that have not been linked to myeloma biology before and are predicted to regulate de novo formed myeloma enhancers (Fig. 2f) display higher connectivity and betweenness (centrality). This evidence concerns the gene XBP1 and plasma cell myeloma.