In total, 138 of 254 expressed TF (Fig. 3a and Supplementary Data 7a–c) displayed higher or similar predicted binding frequency in at least one myeloma subgroup compared to ND PC, and included TF such as XBP1, IRF4 and PRDM1 known to regulate myeloma transcriptomes, but also TF such as CBFB and ZNF384 which have not been previously linked to myeloma biology (Fig. 3a, b and c). This evidence concerns the gene IRF4 and pachyonychia congenita.