These TF, none of which have been previously linked to MM, share another three notable features: (a) they demonstrate dependency on DepMap upon CRISPR/Cas9 and siRNA screens (Fig. 3d and Supplementary Fig. 5g), (b) display highest expression in multiple myeloma cell lines compared to >1000 other cancer cell lines; and (c) their higher expression has a significant adverse impact on survival in two independent myeloma patient cohort datasets (Fig. 4b and c). The gene discussed is TF; the disease is cancer.