CRISPR/Cas9 screens involving depletion of 247/254 TF as retrieved from the DepMap database, suggested myeloma cell dependency on 55% (137/247) of TF in at least 4/20 myeloma cell lines at a CERES score of <−0.2 (Fig. 3d and Supplementary Data 7d), and confirmed MM cell dependency on the TF CBFB and ZNF384 identified by ATAC-seq footprinting (Fig. 3c and d). Here, CBFB is linked to Miyoshi myopathy.