Then, we further detected EMT markers in HCC cells, and the results showed that the mRNA and protein expression of the epithelial marker E-cadherin was increased and that of the mesenchymal marker vimentin was decreased after knocking down PDCD10 in Hep3B cells, whereas PDCD10 overexpression in HepG2 cells resulted in the opposite results (Fig. 3C). The gene discussed is VIM; the disease is hepatocellular carcinoma.