IL6 and neoplasm: For example, the DNA methylation on a single CpG site from Il6 promoter was reported to be related with Il6 mRNA expression levels,27 and single CpG hypermethylation was also reported to be responsible for the decreased tumor suppressor gene expression in cancers.28 Therefore, we believed that the DNA methylation level on this single CpG site might contribute to the AIM2 overexpression in lupus B cells.