AIM2 and systemic lupus erythematosus: Therefore, copied studies have reported the positive association between AIM2-inflammasome and lupus pathogenesis.19,20 Increased expression level of AIM2 was observed in lupus livers, spleens, and peripheral blood mononuclear cells (PBMCs), and enhanced activation of AIM2-inflammasome was found in lupus unstimulated macrophages.20 More interestingly, a reduction of DNA methylation of AIM2 was reported in lupus patients compared with their healthy siblings.21 All the evidence mentioned above suggests that AIM2 is abnormally expressed in lupus immune cells and regulated by DNA methylation.