AIM2 and systemic lupus erythematosus: In order to investigate the effect of IL-10 on histone modification, we conducted ChIP-PCR analysis of H3AC, H3K4me3, H3K9me3, H3K27me3 on AIM2 promoter region, with or without IL-10 treatment and in NC vs active and inactive SLE patients (Supplementary Fig. 7).