Also, TLR1, TLR2, and TLR6 are significantly overexpressed in the BM CD34+ cells of MDS subjects with a higher expression of TLR2 in the BM CD34+ cells of low-risk MDS subjects that induces an increase in the level of β-arrestin-1 and cell death. The gene discussed is TLR6; the disease is myelodysplastic syndrome.