CD40LG and rheumatoid arthritis: In the clinical autoantibody testing, the new biomarker can be used for detecting people “at risk” for RA, and for early and established RA, reducing the sensitivity gap of RF IgM/ α-CCP-2-seronegative patients (sensitivity RF IgM/α-CCP-2 negative LURA/EIRA/predict 32%/73%/100%; Table 1).