ACTA1 and Hepatic fibrosis: In our present study, we found that collagen deposits were significantly increased in CCl4-treated mice (anti-SCR group) as indicated by Masson or Sirius red staining (Fig. 5a and 5b), hydroxyproline (Fig. 5c), as well as the expression of α-SMA (Fig. 5c), suggesting that the mouse model of liver fibrosis induced by CCl4 was successfully established.