For example, Aloe-emodin served as a candidate in the treatment of CRC through upregulating URP proteins and inducing ERS-dependent apoptosis [23]; TSPYL5 suppressed CRC cell proliferation, migration and invasion via activation of ERS, indicating that targeting the ERS response using TSPYL5 might be a promising strategy for CRC treatment [27]. Here, TSPYL5 is linked to colorectal carcinoma.