Mechanistically, these miRNAs (miR-500a-3p, miR-370-3p, miR-2467-3p, miR-512-3p) have multiple binding sites with KCNQ1OT1/XIST and XBP-1u, indicating that KCNQ1OT1/XIST might influence the expression of XBP-1u by competitively binding to these miRNAs, contributing to the progression of CRC. This evidence concerns the gene KCNQ1OT1 and colorectal carcinoma.