According to the literature research, we identified 4 key miRNAs (miR-500a-3p, miR-370-3p, miR-2467-3p, miR-512-3p), based on which, we further identified 4 downregulated lncRNAs (SLFNL1-AS1, KCNQ1OT1, NEAT1, XIST), indicating a potential involvement of these lncRNAs in CRC progression. This evidence concerns the gene SLFNL1 and colorectal carcinoma.