In addition, IHC staining exhibited that the Ki67 (a marker of proliferation) was upregulated while GRP78 was down-regulated by KCNQ1OT1/XIST (Fig. 8G), suggesting that KCNQ1OT1/XIST promoted cancer cell proliferation but inhibited ERS activation. Here, KCNQ1OT1 is linked to cancer.