As for the angiogenesis subtype, ten pathways were found to be upregulated including focal adhesion, pathways in cancer, adherens junction, renal cell carcinoma, regulation of actin cytoskeleton, neurotrophin signaling pathway, ECM receptor interaction, TGF-beta signaling pathway, ERBB signaling pathway, and GAP junction. This evidence concerns the gene BDNF and hereditary clear cell renal cell carcinoma.