However, this vicious circle, Golgi fragmentation↔ER stress↔downregulation of GCC185, does not lead to cell death, implying that PCa cells can trigger a tolerable level of ER stress inter alia by minimizing the contribution of Golgi proteins, such as GCC185, to the critical intracellular events, including apoptosis [47]. This evidence concerns the gene GCC2 and posterior cortical atrophy.