Fourth, it is likely that different bacterial virulence mechanisms such as collagen-binding adhesin (Cna), extracellular adherence protein (Eap), lipoteichoic acid (LTA), wall teichoic acid (WTA) and fibronectin binding proteins A and B (FnBPA and FnBPB) [45] contributed to facilitating the transit of the bacteria through the endothelium in this mouse model of HOIAI as many of these bacterial factors have been implicated in the pathogenesis of osteomyelitis and septic arthritis [52–57]. This evidence concerns the gene PPP3CA and osteomyelitis.