In the current study, multiple-organ damage biomarkers, such as the substantially elevated concentration of AST, LDH, hs-cTnI, CK-MB, PT-INR, NT-proBNP, PT, APTT, PTA, D-dimer and K+, and decreased Ca2+, ALB/GLB, eosinophils and platelet counts, were found to be abnormally dysregulated in non-survivors and were significantly associated with increased death risk of COVID-19. Here, NPPB is linked to COVID-19.