As an example of this the expression of suppressor of cytokine signalling (SOCS) 1 [67, 68] is induced by some T. gondii strains to avoid the effects of IFN-γ while SOCS3 on the other hand is essential for mounting protective immune responses against T. gondii [69], which highlights a complex balance of measures and countermeasures in infection biology. This evidence concerns the gene CISH and infection.