One found that high (vs low) beclin-1immunolabeling in neoplastic rectal carcinoma cells was significantly associatedwith a reduced rate of tumor downstaging following neoadjunctive chemoradiation treatment.53 Another showed that patients with esophageal squamous cell cancer negativefor immunolabeling of beclin-1 and microtubule-associated protein light chain 3(LC3, another autophagy marker) had better overall survival. The gene discussed is MAP1LC3A; the disease is esophageal squamous cell carcinoma.