CD163 and asthma: This investigation identified increased surface expression of CD163 by AMs during thedevelopment of severe airway inflammation, suggesting a previously unidentified rolefor macrophages in the pathogenesis of SEA.25,50 In humans, the production of soluble CD163 by monocytes was upregulated in sepsis;35 however, the association between CD163 expression on AMs and asthma has notbeen investigated.