HIF1A and Hyperglycemia: Three interrelated candidate mechanisms are ER stress (Gulhane et al., 2016) and hyperglycemia (Thaiss et al., 2018), both known to induce mitochondrial ROS production, and stabilization of Hif‐1α in response to superoxide/hydrogen peroxide produced from site IIIQo (Bell et al., 2007; Brunelle et al., 2005; Guzy et al., 2005).