The majority of p97 mutations are associated with a rare disease called Multi System Proteinopathies-1 (MSP-1), which is characterized by a cluster of muscular, bone, and neurological illnesses known as Inclusion Body Myopathy; Paget's Disease of the Bone (PDB); and FrontoTemporal Dementia (FTD) (11). This evidence concerns the gene VCP and frontotemporal dementia.