Consistent with this interpretation, the levels of N‐acetylaspartate (NAA), which maintains energetic integrity during myelination via oligodendroglial aspartoacylase (Francis et al., 2016), were reduced in the dorsolateral prefrontal white matter in major depressive disorder patients as detected by proton magnetic resonance spectroscopy (Wang et al., 2012). Here, ASPA is linked to major depressive disorder.