RASSF1 and choreatic disease: To investigate whether epigenetic changes, including ESRP2 hypermethylation, are associated with other clinical and molecular features, the BCH cohort of WTs were grouped by hierarchical clustering of DNA methylation values at four loci: ESRP2, the WT1 antisense regulatory region [15], H19 [14] and RASSF1A [18] (Fig. S8 and Table S5).