ATP2A1 and myotonic dystrophy type 1: This leads to diverse DM1 features–for example, chloride channel (CLC1) spliceopathy accounts for myotonia, insulin receptor (IR) mis-splicing leads to insulin resistance, cardiac troponin T (cTNT) spliceopathy is linked to cardiac myopathies, and aberrant alternative splicing of sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA1) potentially plays a role muscle wasting [10–15].