However, the endogenous wild-type (non-variant) CREBRF gene/protein has been linked, either directly or indirectly, to many other clinically-relevant physiological and/or pathological processes in mammals, including susceptibility to viral infection [34], endometrial function during pregnancy [36], angiogenesis [40], neuroendocrine function and behavior [17], Alzheimer’s disease [41], and cancer [37, 42–46]. The gene discussed is CREBRF; the disease is early-onset autosomal dominant Alzheimer disease.