Consistent with the Herxheimer staining data showing accelerated LIB formation in HSHA mice, FTIR analysis showed a significantly greater abundance of triglyceride/cholesteryl-esters within the HPF, consistent with findings reported for the association of lipids with amyloid pathology during AD in APP/PS1 mice [28–30] and clinical human tissue [29,31]. Here, APP is linked to Alzheimer disease.