APOB and Brain atrophy: Our results show that hepatic-only expression of genes leading to the synthesis of human-Aβ results in accelerated evolution of LIBs; parenchymal extravasation of apo B lipoproteins, the primary chaperone of blood Aβ; earlier onset of marked neurovascular inflammation; exaggerated cerebral abundance of Aβ; chronically exaggerated rates of neurodegeneration; brain atrophy in regions associated with cognitive performance; and impaired hippocampal-dependent learning.