In our previous experiments in prostate cancer cells, the difference in conversion rate between cells overexpressing adrenal-permissive and adrenal-restrictive forms was much smaller than the difference between 2 cell lines that endogenously expressed (at the mRNA level) similar levels of adrenal-permissive or adrenal-restrictive HSD3B1 (7). The gene discussed is HSD3B1; the disease is Familial prostate cancer.