Alzheimer’s disease (AD) is a degenerative central nervous system (CNS) disorder, characterized by a progressive onset of neurocognitive symptoms, including amnesia, aphasia, disorientation, etc.1 While the etiology of AD remains largely unknown, AD is generally featured by the deposition of β-amyloid (Aβ) and the formation of neurofibrillary tangles of tau protein in CNS. Here, MAPT is linked to Alzheimer disease.