Moreover, growing evidence based on data from patients with Alzheimer's disease (AD) or Parkinson's disease (PD), and animal models thereof has indicated the decreased expression and activity of REST under pathological conditions (Ashton et al., 2017; Huang et al., 2019; Lu et al., 2014; Meyer et al., 2019; Zullo et al., 2019). Here, REST is linked to Alzheimer disease.