HES1 and Hodgkins lymphoma: Our results highlight opportunities for the genetic diagnosis of ski-slope HL and the discovery of novel therapeutic agents, consistent with the results of current clinical trials examining Notch signaling inhibitors for adult-onset HL (Andersson and Lendahl 2014) and a proof-of-concept study regarding hair cell regeneration in adult guinea pigs through siRNA Hes1 modulation (Du et al. 2018), based on the evidence that Notch signaling inhibition promotes differentiation into hair cells in the cochlea (Atkinson et al. 2015; Mizutari et al. 2013).