Exceptions are a subset of multiple myeloma (MM), thyroid carcinoma, and lung cancers (Wang et al., 2012a), where overexpression of DEPTOR eliminates feedback inhibition downstream of mTORC1, resulting in hyperactivation of PI3K/mTORC2/Akt signaling and thereby stimulating cell survival (Peterson et al., 2009). Here, DEPTOR is linked to AL amyloidosis.