LRRC4 and Anxiety: When deleted (Lrrc4−/−) in the mouse, N-Methyl-D-aspartate receptor (NMDAR, an ionotropic glutamate receptor)-dependent synaptic plasticity in the hippocampus was decreased, and these mice displayed mild social interaction deficits, increased self-grooming, and modest anxiety-like behaviors, which were reversed by pharmacological NMDAR activation (Um et al., 2018).