Indeed, we found two additional familial ALS patients with FUS/TBK1 double mutations: FUS c.1540A > G; p.R514G together with TBK1 c.1328_1331del; p.I443Nfs*3 and FUS c.1562G > A; p.R521H in combination with TBK1 c.1522C > A; p.L508I (patients A and C in Table 1). The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.