Specifically, SARS‐CoV‐2 damage to endothelial cells (EC), and subsequent endotheliitis [4] leads to upregulation of heparanase, an endo‐β‐glucuronidase that degrades the heparan sulfate scaffold of the glycocalyx and subendothelial basement membrane, increasing endothelial dysfunction and allowing extravasation of activated immune cells into the extravascular compartment [5, 6]. This evidence concerns the gene HPSE and endothelial dysfunction.