The Risk Score model based on the identified 8 genes, including FOLR3, SLC6A11, ALPP, IGFN1, KCNJ12, RPS4XP22, HIST1H2BH, and BLACAT1, can reliably predict the prognosis of NSCLC patients with or without radiotherapy. Here, RPS4XP22 is linked to non-small cell lung carcinoma.