LASSO Cox regression analysis demonstrated that 8 genes, including FOLR3, SLC6A11, ALPP, IGFN1, KCNJ12, RPS4XP22, HIST1H2BH, and BLACAT1, were closely associated with the prognosis of NSCLC patients. The gene discussed is FOLR3; the disease is non-small cell lung carcinoma.