Finally, the striking results on the normalization of the immune landscape, organ pathology, and cachexia following shSTAT3-based treatment (Fig. 6 and Supplementary information, Fig. S6) clearly finger at STAT3 as the main target in FLIP-expressing myeloid cells and define it as the most deleterious cause of immune and tissue damage during CRS. This evidence concerns the gene CFLAR and congenital rubella syndrome.