Using the streptozotocin-induced AD mice model (Stz), which exhibits structural, neurochemical and behavioral changes that mimic human sporadic AD24,25, we observed that these mice treated with TUDCA showed higher glucose tolerance and insulin sensitivity, reduced fasted and fed glycemia, increased islet mass and beta cell area, as well as potentiated glucose-stimulated insulin secretion, compared with Stz group treated with PBS. Here, INS is linked to Alzheimer disease.