However, for the original aseptic mosquito bite CHMI study, although a trend was present for dose response when comparing number of bites to parasite density at time of malaria diagnosis28, in the current study we did not observe a dose response when comparing number of bites to IgA or IgG responses, suggesting that the sporozoite dose may not explain the increased antibody responses in CHMI compared to natural infection. This evidence concerns the gene CD79A and infection.