The associations of breast cancer risk for ESR1-E2F1, ESR1-TCF12, TCF12-TLE3, and SIN3-TLE3 pairs were significantly stronger in loci also occupied by FOXA1 (P < 1 ×10−5; Fig. 3a, b and Supplementary Table 3). The gene discussed is E2F1; the disease is breast carcinoma.