Interestingly, similar to outcomes seen in RNF5-KD AML cells, RBBP4 KD blocked the growth of AML, but not CML and T-ALL, cell lines (Supplementary Fig. 6a, b), confirming a link between RNF5 and RBBP4 in the context of AML. This evidence concerns the gene RNF5 and acute lymphoblastic leukemia.