Interestingly, KD using RNF5-targeting short hairpin RNAs (shRNF5) decreased viability and attenuated growth of MOLM-13 and U937 AML lines (Fig. 2a and Supplementary Fig. 2a) but not of CML (K-562) or T-ALL (Jurkat) lines (Supplementary Fig. 2b, c). This evidence concerns the gene RNF5 and chronic myelogenous leukemia, BCR-ABL1 positive.