RNF5 and acute myeloid leukemia: Assessment of an independent AML patient cohort (from the Rambam Health Campus Center, Haifa, Israel which included multiple samples obtained from 5 females with a median age of 62 and 6 males with a median age of 63.5, as detailed in Supplementary Table 1) confirmed higher levels of RNF5 protein in AML patient blood samples (n = 18) relative to samples taken from healthy donors (n = 5) (Fig. 1f, g).