Furthermore, when we examined RBBP4 function in vivo using the U937 xenograft model, mice harboring RBBP4 KD in xenografted cells showed delayed AML development and prolonged survival relative to WT-RBBP4 controls, phenocopying changes seen upon RNF5 KD (Fig. 5m, n and Supplementary Fig. 5n, o). Here, RNF5 is linked to acute myeloid leukemia.