Analysis of RNA-seq datasets for various cancer cells in the Cancer Cell Line Encyclopedia (CCLE) database identified a higher copy number and levels of RNF5 transcripts in AML, chronic myeloid leukemia (CML), and T-cell acute lymphoblastic leukemia (T-ALL) relative to other tumor types (Fig. 1a and Supplementary Fig. 1a). Here, RNF5 is linked to T-cell acute lymphoblastic leukemia.