The recently emerged mutations of the S protein in the new “variants of concern” (VOC) 501Y.V3/P.1 (Brazil), 501.V2/B.1.351 (South Africa) and 501Y.V1/B.1.1.7 (UK) generate great worries because they exhibit a significantly higher infection rate and circulate globally59–62. The gene discussed is PROS1; the disease is infection.