PRC1 and neoplasm: Concordantly, genes upregulated upon pharmacologic inhibition of PRC1 in low-risk UM cells (fold change > 1 and Bonferroni <0.05, “PRT-geneset” defined in Fig. 3d) were highly expressed in patient tumor cells with increasing GEP2-like features (Fig. 3e and Supplementary Fig. 8f).