We stratified these pan cancer cell lines (n = 436) based on their SMARCA4/2 expression in tertiles (Supplementary Fig. 2b) and found that SMARCA4Low/SMARCA2Low (A4L/A2L, bottom tertile for both genes) group (n = 53) has the highest half maximal inhibitory concentration (IC50) among all four groups, for common chemotherapy drugs with different mechanisms of action, including cisplatin, cyclophosphamide, topotecan, paclitaxel, etoposide, and 5FU (Fig. 1a, Supplementary Fig. 2c). This evidence concerns the gene SMARCA4 and cancer.