First, we investigated the correlation between chemotherapy responses and mRNA expression levels of SMARCA4/2 in a large cohort of cell lines (n = 436) across different cancer types (Supplementary Fig. 2a), by integrating publicly available drug sensitivity data from Genomics of Drug Sensitivity in Cancer (GDSC)40 and RNA sequencing (RNA-seq) data from Cancer Cell Line Encyclopedia (CCLE)41,42. The gene discussed is SMARCA4; the disease is cancer.