PIK3CA and esophageal squamous cell carcinoma: In addition, the expression of c-myc, which is upregulated by LPCAT1 in patients with lung adenocarcinoma [27], was not enhanced compared with EGFR/PI3K in ESCC cells (Supplementary Fig. 10), which suggests that LPCAT1 may regulate cholesterol synthesis in ESCC cells primarily through these pathways.