In addition, analysis of the clinical tumor samples also showed that the expression of MSMO1 and SQLE was much higher in the tumor tissues compared to that in normal healthy controls and was positively correlated with the expression of LPCAT1 (Supplementary Figs. 5 and 6), while the expression of INSIG-1 showed the opposite results (Supplementary Fig. 7). Here, INSIG1 is linked to neoplasm.