In addition, the expression of c-myc, which is upregulated by LPCAT1 in patients with lung adenocarcinoma [27], was not enhanced compared with EGFR/PI3K in ESCC cells (Supplementary Fig. 10), which suggests that LPCAT1 may regulate cholesterol synthesis in ESCC cells primarily through these pathways. This evidence concerns the gene MYC and esophageal squamous cell carcinoma.