We found associations between relatively prevalent autoantibodies to six antigens and specific psychopathology: anti-AP3B2 (persecutory delusions); anti-TDO2 (hallucinations); anti-CRYGN (insomnia); anti-APMAP (poor appetite), anti-OLFM1 (better cognitive performance); and anti-WHAMMP3 IgG (anhedonia and dysphoria). The gene discussed is CRYGN; the disease is insomnia.