However, there were still 4 out 18 patients showing grade 3 CRS, which might be attributed to tumor lysis syndrome and other cytokines that were significantly elevated during CART therapy, which might involve GM-CSF, G-CSF, MCP-1, TNFA, MIP-1, IL8, IL13, and IL10. This evidence concerns the gene IL10 and Tumor Lysis Syndrome.