It has been shown that both loss of wt and gain of mutant HTT in HD decreases the levels of the neurotrophic factor BDNF (Zuccato et al., 2001, 2003; Gauthier et al., 2004) and increasing BDNF signaling rescues synaptic plasticity and memory in HD mice (Lynch et al., 2007; Anglada-Huguet et al., 2016). This evidence concerns the gene BDNF and Huntington disease.